Latest Publications

Martinez N. M., Su A., Burns M.C., Nussbacher J.K., Sathe S., Yeo G.W. and Gilbert W.V. (2022) Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing. Mol Cell. ISSN 1097-2765.

Martinez N. M., Schaening-Burgos C. and Gilbert W. V. Pseudouridine site assignment by high-throughput in vitroRNA pseudouridylation and sequencing (2021). Methods Enymol 658, 277-310. doi: 10.1016/bs.mie.2021.06.026.

Martinez NM, Gilbert WV. Investigating Pseudouridylation Mechanisms by High-Throughput in Vitro RNA Pseudouridylation and Sequencing. Methods Mol Biol. 2021;2298:379-397. doi: 10.1007/978-1-0716-1374-0_22.

Borchardt E.K.*, Martinez N. M.*, Gilbert W. V. (2020). Regulation and Function of RNA Pseudouridylation in Human Cells. Annu. Rev. Genet. 54:14.1–14.28. * denotes equal contribution. doi: 10.1146/annurev-genet-112618-043830.

Carlile T.M., Martinez N.M., Schaening C., Su A., Bell T.A., Zinshteyn B. and Gilbert W.V. (2019) mRNA structure determines modification by pseudouridine synthase 1. Nat Chem Bio 15, 966–974. doi: 10.1038/s41589-019-0353.

Martinez, N.M. & Gilbert, W.V. Pre-mRNA modifications and their role in nuclear processing. Quant Biol (2018) 6: 210. doi: 10.1007/s40484-018-0147-4.

Other Publications

Ajith S., Gazzara M.R., Cole B.S., Shankarling G., Martinez N.M., Mallory M.J., Lynch K.W. (2016) Position-dependent activity of CELF2 in the regulation of splicing and implications for signal-responsive regulation in T cells. RNA Biol. 2016 Jun 2;13(6):569-81.

Boskovic Z.V., Kemp M.M., Freedy A.M., Viswanathan V.S., Pop M.S., Fuller J.H., Martinez N.M., Figueroa Lazú S.O., Hong J.A., Lewis T.A., Calarese D., Love J.D., Vetere A., Almo S.C., Schreiber S.L., Koehler A.N. (2016) Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

Sotillo E., Barrett D.M., Black K.L., Bagashev A., Oldridge D., Wu G., Sussman R., Lanauze C., Ruella M., Gazzara M.R., Martinez N.M., Harrington C.T., Chung E.Y., Perazzelli J., Hofmann T.J., Maude S.L., Raman P., Barrera A., Gill S., Lacey S.F., Melenhorst J.J., Allman D., Jacoby E., Fry T., Mackall C., Barash Y., Lynch K.W., Maris J.M., Grupp S.A., Thomas-Tikhonenko A. (2015) Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy. Cancer Discov. 5(12):1282-95.

Martinez N.M., Agosto L., Qiu J., Mallory M.J., Gazzara M.R., Barash Y., Fu XD., Lynch K.W. (2015) Widespread JNK-dependent Alternative Splicing Induces a Positive Feedback Loop through CELF2-mediated regulation of MKK7 during T Cell Activation. Genes Dev, 29 (19), 2054-2066.

Mallory M.J., Allon S.J., Qiu J., Gazzara M.R., Tapescu I., Martinez N.M., Fu X.D. and Lynch K.W. (2015) Induced transcription and stability of CELF2 mRNA drives widespread alternative splicing during T cell signaling. PNAS 122(17):E2139-48.

Martinez, N.M., and Lynch, K.W. (2013). Control of alternative splicing in immune responses: many regulators, many predictions, much still to learn. Immunol. Rev. 253, 216–236.

Martinez, N.M., Pan, Q., Cole, B.S., Yarosh, C.A., Babcock, G.A., Heyd, F., Zhu, W., Ajith, S., Blencowe, B.J., and Lynch, K.W. (2012). Alternative splicing networks regulated by signaling in human T cells. RNA 18, 1029–1040.

Kemp M.M., Wang Q., Fuller J.H., West N., Martinez N.M., Morse E.M., Weïwer M., Schreiber S.L., Bradner J.E.and Koehler A.N. (2011). A Novel HDAC Inhibitor with a Hydroxy-Pyrimidine Scaffold. Bioorg. Med. Chem. Lett21(14):4164-9.

Please visit our NIH bibliography for the complete list of publications »